Studies have found that when taken along with an inhaler, Pycnogenol can reduce leukotrienes, helping to relieve lung inflammation and limit frequency of inhaler use., Many people develop osteoarthritis as they age. DOI: Gulati OP. Align your health hacks with your genes for optimal health & cognitive function. This makes it very hard to set a standard dose. It has many health benefits, and may help protect against several chronic conditions. Pycnogenol also treatment improved blood vessel function. Eighty-six patients were treated either with Pycnogenol at 150 mg or 300 mg daily or the drugs diosmin and hesperidin (Daflon)at 1,000 mg daily for two months. Are there any risks to taking it? For diseases of the retina, including those related to diabetes: 50 milligrams three times daily. Blazs G, et al. They were treated with 200 mg of Pycnogenol daily or with placebo. But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? It does this by improving the time it takes the body to reach a fatigued state through increased serum NAD+ levels. According to some researchers, Pycnogenol may lower blood pressure by relaxing blood vessels, reducing free radicals, and lowering inflammation. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. In another study, Pycnogenol increased glutathione levels and total antioxidants after a month in children with ADHD [42, 43]. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD) [Abstract]. If possible, try to get pine bark extract from a local supplier, such as a health food store. He later extracted proanthocyanidins from the European coastal pine tree, which he named Pycnogenol.. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. Information is shared for educational purposes only. Some people seek to manage ADHD symptoms through an ADHD diet. - Apply a hot compress to the anus or soaking it in a shallow tub of hot water several times a day. If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. In a study of 61 ADHD children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. (2013). The positive improvements in symptoms were greater among those taking Pycnogenol. A combination supplement (pycnogenol with collagen, coenzyme Q10, and other ingredients) reduced skin aging, elasticity, hydration, and tonicity in a study of 30 women [65]. A study of 58 people with high blood pressure suggests that even lower doses (100 mg/day) may improve blood vessel health and reduce markers of high blood pressure (endothelin-1) after 12 weeks. 2005-2023 Healthline Media a Red Ventures Company. Another highlight of grapes nutrition is the presence of polyphenols, which have been shown to decrease chronic inflammation. If youre wondering how to get an even skin tone, there are plenty of remedies that can help. Interactions. It has been studied for its effects on everything from mental function to treating high blood pressure. Researchers suggest that Pycnogenol may reduce cough, night-awakenings, improve airway flow, and the need for additional asthma medication [16]. You can refer to the National Institutes of Healths dosage guidelines for specific conditions. Some small studies suggest it may also protect against coronary artery disease and blood clots. Chemistry. but is for informational and educational purposes alone. Pine bark extract provides many benefits to the skin, including reducing the signs of aging. Therefore, those who have autoimmune conditions could see their symptoms increase after taking it., Since Pycnogenol is used for so many conditions, doses can vary. Our team aims to be not only thorough with its research, but also objective and unbiased. A sitz bath, which involves sitting in warm water for 10 minutes, twice daily, is helpful to patients with anal itching, aching or burning and is known as one of the best ways to get rid of hemorrhoids fast. It can then lead to heart problems like stroke or heart attack. Pycnogenol French maritime pine bark extract's 4 basic properties. Discover what the research says about elimination diets, foods to eat, and more. In oneparticular study published in Research in Pharmaceutical Sciences, researchers investigated the antibacterial activity of pine bark extract essential oil on staph infections, E. coli and pseudomonas infections. While much of this is positive, it will be a while before doctors routinely recommend this dietary supplement for these conditions. Still, more research is needed to better understand these findings and pine bark extracts role in reducing damage from head trauma. She is a strong advocate of integrating scientific knowledge and holistic medicine. Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). So it . In addition to OPC, grape seed extract contains linoleic acid, flavonoids and phenolic procyanidins that help protect and strengthen capillaries, blood vessels, veins and arteries, which can then improve blood circulation. But the actual bioavailability of this complex mixture is still unknown. In the study, it reduced cold symptoms and complications, the number of lost working days, and the use of over-the-counter medications compared to those who did not supplement with the extract [60]. Instead, use plain water to wipe yourself and then dry your bottom afterward. Lower the risk of Alzheimer's disease. But two months ago, erectile dysfunction health food with the help of the Divine Tool Alliance, the price of all materials related to the puppet mechanism was raised by 20 erectile dysfunction health food 30 , and the price of selling the puppet was reduced by 10. Some studies also suggest it can help guard against coronary artery disease and blood clots, per webmd.com. Enzogenol, a slightly different pine bark extract, improved cognitive function in a clinical trial of 42 older men after 5 weeks of supplementation [23]. This is thought to be due to pine bark extracts ability to reduce oxidative stress and inflammation. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. Trees of this pine have been naturalized in Australia and New Zealand, where most Enzogenol is now made [7]. Pycnogenol treatment lowered the ACE-inhibitor dose required to control blood pressure, and lowered fasting glucose levels as well. Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. It comes from the bark of a European pine tree. However, it's always a good idea to start with a low dose so you can monitor how your body responds. Here are some basic guidelines as reported by WebMD: While most studies do not indicate major side effects, pine bark extract may cause irritability and fatigue, and could interact with other drugs. Last medically reviewed on January 24, 2018. Score one for diabetes control and fewer risk factors for the heart. A clinically studied blend of Pycnogenol and a special bilberry extract (called Mirtogenol ) has been shown to provide benefits for vision and eye health. A clinical trial of 57 ADHD children found that daily Pycnogenol (1 mg/kg) for one month may reduce hyperactivity symptoms. Pycnogenol; Pycnogenol. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. Pycnogenol treatment led to significantly better improvement in the lung function and asthma symptoms. Pycnogenol is considered possibly safe when taken orally or when applied topically as a cream or ointment. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. In a study of 72 children undergoing cancer chemotherapy, Pycnogenol reduced painful mouth ulcers, both alone and in combination with vitamin E [79]. Add to Cart. They include: We need more research to know for sure if pycnogenol helps treat these conditions. Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [emailprotected]. A study of 32 people with heart failure lasting 12 weeks suggests that a combination of Pycnogenol with CoQ10 (PycnoQ10) may improve blood pressure, heart function, edema, and capacity for physical activity [40]. The outcome showed significant healing when compared to those subjects who were not given any drug or remedy, concluding that Pycnogenol may be an effective remedy for healing of surgery-related lesions. In 24 people with early eye damage from diabetes, Pycnogenol improved vision, reduced eye swelling, and improved circulation in the eye after 2 months. are clickable links to medically peer-reviewed studies. Pycnogenol significantly reduced the swelling as well as the feeling of heaviness. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Andrographis is a medicinal herb used to treat many health conditions, such as the common cold, osteoarthritis, and ulcerative colitis. Pycnogenol is the registered trademark brand name of French maritime pine bark extract. The results of a 2013 animal study suggest that pine bark extract may help to reduce damage to nerve cells following a traumatic brain injury. Another study of 47 women found that supplementing with 30 mg Pycnogenol twice daily for over 1 month may reduce menstrual pain [73]. It is standardized to contain 65-75% procyanidins, a class of polyphenols and flavonoids like those found in blueberries, wine, grape skin, citrus, and cocoa. Possible side effects . But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. (4). Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. Quality and active ingredients in supplements may vary widely from maker to maker. This study adds to a body of research showing the benefits of Pycnogenol . 7. Enzogenol, a slightly different pine bark extract, may help improve brain function after mild concussions. It can also stabilize mast cells, which release histamine and trigger allergic reactions. DOI: Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 50 to 450 milligrams of pine bark extract daily, Supplements During Pregnancy: Whats Safe and Whats Not, The ADHD Diet: What Works and What Does Not, Berberine A Powerful Supplement With Many Benefits, The Top Health Benefits of Prunes and Prune Juice, What to Know About Andrographis Supplements: Potential Benefits and Uses, Kerry Boyle D.Ac., M.S., L.Ac., Dipl. In a study of 33 people with severe osteoarthritis, pycnogenol (200 mg/day) reduced inflammatory markers after 3 weeks. It had the best results when combined with compression stockings, but worked just as well alone [28]. In another study, 45 men with ED were given 1.7 grams of L-arginine a day during the first month, 40 mg Pycnogenol twice daily during the second month, and the dose increased to three 40-mg Pycnogenol doses daily during the third month. In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. The dosage in most clinical studies varied between 50-360 mg/day. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. The researchers concluded that pine bark extract may increase production of hyaluronic acid and collagen, which are both found in many popular antiaging products. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Disclaimer: Results are not guaranteed*** and may vary from person to person***. The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. In contrast, almost 20% of the participants on inhalers alone had to increase their dosage. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. It is found primarily in southwestern France and is used to help people with asthma, allergies, hay fever, and other health conditions.. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. Diarrhea. These benefits appeared to persist for some time even after stopping supplementation [72]. Subjects in the study that took Pycnogenol ended up taking fewer painkillers [51]. New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. Studies have shown that the tree bark can help decrease common symptoms including hot flashes, mood swings, irregular periods, and others. Not bad. WebMD does not provide medical advice, diagnosis or treatment. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. For improving exercise capacity in athletes: 200 milligrams daily. There havent been any studies looking at long-term liver damage. Can Pycnogenol help? Pycnogenol is the US trademarked name for an antioxidant made from Mediterranean tree bark. The study showed that many people who participated had a drop in their systolic blood pressure after taking Pycnogenol. 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Pycnogenol can help control blood pressure, which helps improve overall heart health. A good-quality study was conducted in 77 diabetic patients who received their standard antidiabetic treatment along with 100 mg Pycnogenol a day or placebo for 12 weeks. In one trial of 77 people with type 2 diabetes, pycnogenol (100 mg/day) for 12 weeks lowered both blood sugar levels and HbA1c, a marker of long-term blood glucose levels [31]. Eye health. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. Tell your doctor about any supplements you're taking, even if they're natural. Pycnogenol may help reduce symptoms of melasma, a form of hyperpigmentation, possibly because it protects against UV rays. Research indicates that Pycnogenol provides an increase in endurance performance of trained athletes. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. The authors attributed the negative results to the short duration of treatment and the low dosages of drug or Pycnogenol. Pycnogenol has not been found to cause these issues however, it may take a little longer the feel the relief from pain than aspirin.